To speak of Chicago blues is to speak of Muddy Waters, who, firmly rooted in the deep blues of the Mississippi Delta, always kept the essence of the genre alive through all the musical trends of his time, from rock and roll to the folk boom, passing through flower power, psychedelia, and the sounds of 1960s British pop. Born and raised in the Mississippi Delta in 1913, he began his career alongside bluesmen of the caliber of Son House and Robert Johnson in the mid-1930s. In 1947, he signed with the blues-focused label Chess Records, with whom he began recording alongside Little Walter, Jimmy Rogers, and Otis Spann. After an endless succession of singles and albums, he recorded "The London Muddy Waters Sessions" in 1972, with a number of highly acclaimed white musicians. These musicians included Rory Gallagher, Georgie Fame, Rick Grech, Steve Winwood, and Mitch Mitchell, among others. This legendary recording yielded some breathtaking blues sessions, such as Willie Dixon's versions of "Young Fashioned Ways", "Walkin' Blues", and "I'm Ready", and Big Bill Broonzy's "Key to the Highway". "The London Muddy Waters Sessions" is a landmark document of the blues and is considered one of the genre's high points.

